Are GPR M 1/500MG and GLIMO M1 the same?

Yes, GPR M 1/500MG and GLIMO M1 contain the same active salt (GLIMEPIRIDE 1MG + METFORMIN 500MG) in the same strength and provide identical therapeutic efficacy, meeting strict quality and safety standards.

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Diabetes Care

GPR M 1/500MG

Name: GPR M 1/500MG
Brand: Medingen
SKU: 44685
Price: 16.00 INR
Availability: InStock

Composition:GLIMEPIRIDE 1MGMETFORMIN 500MG10'S

₹16₹51.56Saving: ₹35.56

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GPR M 1/500MG tablet contains glimepiride + metformin, a combination oral anti-diabetic medicine used to manage type 2 diabetes mellitus in adults when diet, exercise, or a single medicine alone is not enough. It combines a sulfonylurea with a biguanide to improve blood sugar control through dual action—one component helps the pancreas release more insulin, while the other reduces glucose production in the liver and improves insulin sensitivity. GPR M 1/500MG tablet is commonly available in strengths such as 1 mg/500 mg, 2 mg/500 mg, and sustained-release variants, with the exact GPR M 1/500MG dosage chosen according to blood sugar levels, HbA1c, and kidney function. Regular use helps reduce long-term risks affecting the eyes, kidneys, nerves, and heart.

Pharmacist Note

Take GPR M 1/500MG tablet with food, preferably your first main meal, to reduce stomach upset and lower the risk of low blood sugar. Do not skip meals after taking it, and keep glucose powder, sugar candy, or fruit juice nearby in case you feel sweating, tremors, or sudden weakness. Long-term use may need vitamin B12 monitoring.

Type 2 Diabetes Control

GPR M 1/500MG tablet helps lower high blood sugar in adults with type 2 diabetes when lifestyle changes alone are not enough. Better sugar control supports healthier HbA1c levels and reduces the risk of long-term complications like kidney disease, neuropathy, and diabetic eye damage.

Dual Glucose-lowering Action

GPR M 1/500MG tablet offers two complementary mechanisms in one medicine. It helps improve insulin release while also reducing glucose production from the liver, making it effective for both fasting and post-meal sugar control.

Supports Better Hba1c Reduction

GPR M 1/500MG tablet is often prescribed when single-drug treatment does not provide target glucose control. The combination approach may offer stronger HbA1c reduction and more stable day-to-day sugar readings.

Convenient Combination Therapy

By combining two anti-diabetic agents into one tablet, GPR M 1/500MG tablet improves convenience and may reduce pill burden. This can help improve adherence in patients who need long-term diabetes treatment.

While generally safe and well-tolerated, high doses or sensitivity can cause some side effects.

Type

Symptoms

Severity

Common

Nausea, diarrhea, stomach discomfort, headache, dizziness

Common

Moderate

Low blood sugar, metallic taste, weakness, gas, bloating

Occasional

Serious

Lactic acidosis, severe hypoglycemia, jaundice, allergic swe... show more

Rare

Dosage

The GPR M 1/500MG dosage is individualized based on fasting sugar, post-meal su... show more

Timing

Take GPR M 1/500MG tablet with breakfast or the first major meal of the day. Sw... show more

Limit

Do not exceed the prescribed GPR M 1/500MG dosage, even if your sugar readings ... show more

Consistency

Take GPR M 1/500MG tablet at the same time every day for stable glucose control... show more

GPR M 1/500MG tablet works through a dual mechanism to control blood sugar. One component stimulates the pancreas to release insulin, helping move glucose from the blood into cells, while the other reduces glucose production in the liver and improves insulin sensitivity in muscles and tissues. This combined effect helps control both fasting and after-meal sugar levels more effectively than single-drug therapy.

Pregnancy

GPR M 1/500MG tablet should only be used in pregnancy if clearly prescribed by a doctor. In many cases, insulin may be preferred for tighter blood sugar control during pregnancy.

Alcohol

Avoid alcohol while taking GPR M 1/500MG tablet because it can increase the risk of low blood sugar and a rare but serious condition called lactic acidosis. Even occasional drinking should be discussed with your doctor.

Driving

GPR M 1/500MG tablet may cause dizziness, blurred vision, or sweating if blood sugar drops too low. Check your glucose before long drives and avoid driving if symptoms appear.

Kidney

Patients with kidney disease require careful dose adjustment because GPR M 1/500MG tablet may accumulate and increase side effects. Kidney function tests should be checked before and during treatment.

Elderly

Older adults may be more prone to low blood sugar and stomach-related GPR M 1/500MG side effects. Lower initial doses and regular renal monitoring are usually recommended.

Children

GPR M 1/500MG tablet is generally not routinely recommended in children unless prescribed by a specialist. Safety and dosing depend on age, weight, and diabetes severity.

Insulin (Antidiabetic)

May greatly increase the glucose-lowering effect of GPR M 1/500MG tablet and raise the risk of severe hypoglycemia.

High

Fluconazole (Antifungal)

May increase blood levels and prolong the action of GPR M 1/500MG tablet, increasing low sugar risk.

High

Corticosteroids (e.g., Prednisolone)

May reduce the sugar-lowering effectiveness of GPR M 1/500MG tablet and worsen glucose control.

Moderate

Furosemide (Diuretic)

May affect kidney function and increase the risk of dehydration-related side effects with GPR M 1/500MG tablet.

Moderate

What are the common GPR M 1/500MG tablet uses?

The most common GPR M 1/500MG tablet uses include controlling blood sugar in type 2 diabetes when one medicine alone is insufficient. It is especially helpful for patients needing both fasting and post-meal sugar control.

Can GPR M 1/500MG tablet cause low blood sugar?

Yes, one of the important GPR M 1/500MG side effects is hypoglycemia, especially if meals are delayed, skipped, or after heavy exercise. Always carry a quick sugar source and monitor glucose regularly.

Can GPR M 1/500MG tablet cause stomach upset?

Yes, nausea, gas, bloating, and loose stools are common early GPR M 1/500MG side effects. Taking it with food and following the prescribed GPR M 1/500MG dosage usually improves tolerance.

What happens if I miss a dose of GPR M 1/500MG tablet?

Take the missed dose with food as soon as you remember on the same day. If it is close to the next scheduled GPR M 1/500MG dosage, skip the missed one and continue normally without doubling.

How long should I take GPR M 1/500MG tablet?

GPR M 1/500MG tablet uses are usually long-term because type 2 diabetes requires ongoing management. Continue taking it regularly unless your doctor changes the treatment based on HbA1c, weight, or kidney function.

NICE – https://www.nice.org.uk/guidance/ng28
MIMS India – https://www.mims.com/india/drug/info/glimepiride-plus-metformin
PharmEasy – https://pharmeasy.in/molecules/metformin-glimepiride-9958
Tata 1mg – https://www.1mg.com/generics/glimepiride-metformin-401791
Mayo Clinic – https://www.mayoclinic.org/diseases-conditions/type-2-diabetes

Disclaimer

: The information provided on this page is for informational and educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.

WRITTEN BY

Dr. Helan, PharmD

REVIEWED BY

Dr. Lakshmi MBBS, MD

LAST UPDATED

Oct 12, 2024