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diabetes care

GMPIO 2MG

Name: GMPIO 2MG
Brand: PCHPL PSYCHOCARE HEALTH PVT.LTD
SKU: 34119
Price: 38.00 INR
Availability: InStock

Composition:GLIMEPIRIDE 2MGPIOGLITAZONE 15MGMETFORMIN 500MG10'S

Brand: PCHPL PSYCHOCARE HEALTH PVT.LTD

₹38₹90.75Saving: ₹52.75

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GMPIO 2MG tablet contains glimepiride + pioglitazone + metformin, a triple-combination oral anti-diabetic medicine used for adults with type 2 diabetes mellitus when diet, exercise, and dual therapy do not provide adequate control. It combines a sulfonylurea, a thiazolidinedione, and a biguanide to provide three-way blood sugar control—one improves insulin release, another increases insulin sensitivity, and the third reduces glucose production in the liver while improving peripheral glucose use. GMPIO 2MG tablet is commonly available in strengths such as 1 mg/15 mg/500 mg and 2 mg/15 mg/500 mg, with the GMPIO 2MG dosage adjusted according to HbA1c, fasting glucose, weight, and kidney function. Regular use helps reduce long-term diabetes complications affecting the eyes, kidneys, nerves, and heart.

Pharmacist Note

Take GMPIO 2MG tablet with your first main meal to reduce stomach upset and help lower the risk of low blood sugar. Because this combination may also cause fluid retention, monitor for ankle swelling, sudden weight gain, or shortness of breath and report these symptoms early. Regular blood sugar, liver function, and kidney monitoring are important during long-term use.

Advanced Type 2 Diabetes Control

GMPIO 2MG tablet helps manage type 2 diabetes when two medicines are not enough to achieve target glucose levels. Better control supports HbA1c improvement and lowers the long-term risk of diabetic kidney disease, nerve damage, and eye complications.

Triple Mechanism Blood Sugar Action

GMPIO 2MG tablet works through three complementary pathways for stronger glucose control. It boosts insulin release, improves insulin sensitivity in muscles and fat tissue, and reduces excess glucose production from the liver.

Helps Improve Insulin Resistance

GMPIO 2MG tablet is especially useful in patients with marked insulin resistance and uncontrolled fasting sugars. By improving how the body responds to insulin, it may help achieve steadier day-to-day glucose readings.

Convenient Fixed-dose Therapy

By combining three medicines into one tablet, GMPIO 2MG tablet reduces pill burden and improves convenience. This often supports better adherence in patients needing long-term diabetes management.

While generally safe and well-tolerated, high doses or sensitivity can cause some side effects.

Type

Symptoms

Severity

Common

Nausea, diarrhea, headache, dizziness, swelling of feet/ankl... show more

Common

Moderate

Low blood sugar, weight gain, gas, weakness, mild anemia

Occasional

Serious

Severe hypoglycemia, lactic acidosis, heart failure worsenin... show more

Rare

Dosage

The GMPIO 2MG dosage is individualized based on fasting sugar, post-meal sugar, ... show more

Timing

Take GMPIO 2MG tablet with breakfast or the first major meal of the day. Swallow... show more

Limit

Do not exceed the prescribed GMPIO 2MG dosage even if sugar readings are tempora... show more

Consistency

Take GMPIO 2MG tablet at the same time every day for steady glucose control. Irr... show more

GMPIO 2MG tablet works through three glucose-lowering actions. One component stimulates the pancreas to release insulin, another improves insulin sensitivity in muscles and fat tissues, while the third lowers glucose production in the liver and reduces intestinal glucose absorption. This combined effect helps control fasting and post-meal blood sugar more effectively and supports better long-term HbA1c management.

Pregnancy

GMPIO 2MG tablet should only be used in pregnancy if specifically prescribed by a doctor. Insulin is usually preferred for safer and tighter blood sugar control during pregnancy.

Alcohol

Avoid alcohol while taking GMPIO 2MG tablet because it can increase the risk of low blood sugar and metformin-related lactic acidosis. It may also worsen dizziness or dehydration.

Driving

GMPIO 2MG tablet may cause dizziness, sweating, tremors, or blurred vision if blood sugar drops too low. Check glucose levels before driving and avoid long drives if symptoms occur.

Kidney

Patients with kidney disease may require careful dose adjustment because metformin can accumulate and increase side effects. Regular renal function monitoring is important during therapy.

Elderly

Older adults may be more sensitive to GMPIO 2MG side effects such as hypoglycemia, swelling, and stomach upset. Lower initial doses and close monitoring are commonly recommended.

Children

GMPIO 2MG tablet is generally not routinely recommended in children unless prescribed by a specialist. Safety and dosing depend on age, body weight, and diabetes severity.

Insulin (Antidiabetic)

May significantly increase the glucose-lowering effect of GMPIO 2MG tablet and raise severe hypoglycemia risk.

High

Gemfibrozil (Lipid-lowering agent)

May increase pioglitazone levels and raise the risk of swelling or weight gain with GMPIO 2MG tablet.

High

Prednisolone (Steroid)

May reduce the sugar-lowering effect of GMPIO 2MG tablet and worsen glucose control.

Moderate

Furosemide (Diuretic)

May increase dehydration risk and worsen kidney-related side effects with GMPIO 2MG tablet.

Moderate

What are the main GMPIO 2MG tablet uses?

The main GMPIO 2MG tablet uses include controlling blood sugar in type 2 diabetes when dual therapy is insufficient. It is especially useful for patients with insulin resistance, high fasting sugar, and elevated HbA1c.

Can GMPIO 2MG tablet cause swelling?

Yes, swelling of the feet or ankles is one of the known GMPIO 2MG side effects due to the pioglitazone component. Inform your doctor if swelling is persistent, associated with weight gain, or causes breathing discomfort.

Can GMPIO 2MG tablet cause low blood sugar?

Yes, an important GMPIO 2MG side effect is hypoglycemia, especially if meals are skipped or physical activity suddenly increases. Always keep a quick sugar source nearby and monitor blood glucose regularly.

What should I do if I miss a dose of GMPIO 2MG tablet?

Take the missed dose with food as soon as you remember on the same day. If it is near the next GMPIO 2MG dosage time, skip the missed dose and continue normally without doubling.

How long should I continue GMPIO 2MG tablet uses?

GMPIO 2MG tablet uses are usually long-term because type 2 diabetes needs continuous management. Your doctor may continue or modify therapy depending on HbA1c, weight, swelling risk, and kidney tests.

Tata 1mg – https://www.1mg.com/generics/glimepiride-metformin-pioglitazone-401792
NICE – https://www.nice.org.uk/guidance/ng28
Mayo Clinic – https://www.mayoclinic.org/drugs-supplements/pioglitazone-and-metformin-oral-route/description/drg-20063126
Mayo Clinic – https://www.mayoclinic.org/drugs-supplements/pioglitazone-and-glimepiride-oral-route/description/drg-20068956
Drugs.com – https://www.drugs.com/mtm/glimepiride-and-pioglitazone.html

Disclaimer

: The information provided on this page is for informational and educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.

WRITTEN BY

Dr. Helan, PharmD

REVIEWED BY

Dr. Lakshmi MBBS, MD

LAST UPDATED

Oct 12, 2024